A powerful procedure that controls the false discovery rate with directional information

Zhaoyang Tian, Kun Liang and Pengfei Li

Biometrics, 2021, vol. 77, issue 1, 212-222

Abstract: In many multiple testing applications in genetics, the signs of the test statistics provide useful directional information, such as whether genes are potentially up‐ or down‐regulated between two experimental conditions. However, most existing procedures that control the false discovery rate (FDR) are P‐value based and ignore such directional information. We introduce a novel procedure, the signed‐knockoff procedure, to utilize the directional information and control the FDR in finite samples. We demonstrate the power advantage of our procedure through simulation studies and two real applications.

Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://doi.org/10.1111/biom.13277

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:bla:biomet:v:77:y:2021:i:1:p:212-222

Ordering information: This journal article can be ordered from
http://www.blackwell ... bs.asp?ref=0006-341X

Access Statistics for this article

More articles in Biometrics from The International Biometric Society
Bibliographic data for series maintained by Wiley Content Delivery ().