Direct Economic Burden of Post‐Cancer Treatment Pain Among Cancer Survivors in the United States: A Population‐Based Retrospective Longitudinal Study

Yves Paul Vincent Mbous, Rowida Mohamed, Uche Osahor and Traci J. LeMasters

International Journal of Health Planning and Management, 2025, vol. 40, issue 4, 935-947

Abstract: Purpose Post‐cancer treatment pain (PCTP) is prevalent among cancer survivors but remains understudied. It is critical to quantify PCTP prevalence over time and to estimate the resulting short and long‐term incremental healthcare expenditures (total, third‐party, and out‐of‐pocket) and out‐of‐pocket burden among cancer survivors. Methods A longitudinal retrospective cohort design was used. To identify cancer survivors (≥ 18 years) with PCTP, the Medical Expenditure Panel Survey (MEPS) and its supplementary Cancer Self‐Administered Questionnaire (CSAQ)were used. Recycled predictions from generalised linear models (GLM) with log‐link and gamma distribution were used to estimate annual incremental healthcare expenditures at different PCTP gradations over time. To account for covariate imbalance, sensitivity analysis using inverse probability weighting was conducted. Results 2125 cancer survivors had PCTP. Post‐cancer treatment, 10.5%–24.2% of survivors experienced some form of chronic PCTP, whereas between 21.9%–5.1% experienced acute PCTP. Across the survivorship journey, the adjusted total annual incremental healthcare expenditures were the highest among cancer survivors with moderate chronic PCTP (

Date: 2025
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