The Epidemiology of Childhood Leukaemia

Richard Doll

Journal of the Royal Statistical Society Series A, 1989, vol. 152, issue 3, 341-351

Abstract: Leukaemias are of several types, the proportion attributable to each varying with age. The causes of most childhood leukaemias are unknown. A few are associated with genetic abnormalities and a few to chemotherapy given after birth. Many more are due to exposure to ionizing radiation with possibly 8% attributable to exposure to natural radiation in utero. Clues to aetiology may be obtained from the age distribution of the disease and the variation in incidence with place, ethnicity, socioeconomic conditions and time; but much of the variation is likely to be a nosological artefact. The existence of clusters in space and time, which would point to the importance of environmental factors, has long been suspected but is unproved.

Date: 1989
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