Quality‐Of‐Life Assessment: Can We Keep it Simple?

D. R. Cox, R. Fitzpatrick, A. E. Fletcher, S. M. Gore, D. J. Spiegelhalter and D. R. Jones

Journal of the Royal Statistical Society Series A, 1992, vol. 155, issue 3, 353-375

Abstract: The importance of general statistical principles of study design and analysis to quality‐of‐life assessment in clinical trials is emphasized. Basic methods are reviewed briefly, with reference to three examples. Careful use of standard tools supplemented with context‐specific scales is recommended. Problems of weighting and aggregation are discussed; the use of simple weighting schemes supplemented by sensitivity analysis is suggested. Some technical issues are explored, including factorial question structure, components of variance to distinguish mean treatment and patient‐specific treatment effects and informative loss to follow‐up. Simplicity of design, analysis and presentation are stressed.

Date: 1992
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