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Selecting Confounders from Covariates

Gillian M. Raab

Journal of the Royal Statistical Society Series A, 1994, vol. 157, issue 2, 271-283

Abstract: Most analyses of observational studies to investigate the relationship between a risk factor and an outcome use some data‐dependent method to select a subset of the available covariates to include as confounders. This paper evaluates methods which can be used to make this selection in linear models. The methods are applied to the selection of covariates in a study of the effect of lead in the blood on children's ability and are evaluated by a simulation study on multivariate normal data. None of the methods can be guaranteed to give satisfactory results in all cases, and all the methods can result in misleading inferences. Recommendations for the design and analysis of observational studies are made in the light of these results.

Date: 1994
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