 Parameter Orthogonality in Mixed Regression Models for Survival DataJ. L. Hutton and P. J. Solomon Journal of the Royal Statistical Society Series B, 1997, vol. 59, issue 1, 125-136 Abstract: The implications of parameter orthogonality for the robustness of survival regression models are considered. The question of which of the proportional hazards or the accelerated life families of models would be more appropriate for analysis is usually ignored, and the proportional hazards family is applied, particularly in medicine, for convenience. Accelerated life models have conventionally been used in reliability applications. We propose a one‐parameter family mixture survival model which includes both the accelerated life and the proportional hazards models. By orthogonalizing relative to the mixture parameter, we can show that, for small effects of the covariates, the regression parameters under the alternative families agree to within a constant. This recovers a known misspecification result. We use notions of parameter orthogonality to explore robustness to other types of misspecification including misspecified base‐line hazards. The results hold in the presence of censoring. We also study the important question of when proportionality matters. Date: 1997 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:bla:jorssb:v:59:y:1997:i:1:p:125-136 Ordering information: This journal article can be ordered from Access Statistics for this article Journal of the Royal Statistical Society Series B is currently edited by P. Fryzlewicz and I. Van Keilegom More articles in Journal of the Royal Statistical Society Series B from Royal Statistical Society Contact information at EDIRC. |
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