On the Representativeness Assumption in Prevalence Tests of Carcinogenicity

S. W. Lagakos and Louise M. Ryan

Journal of the Royal Statistical Society Series C, 1985, vol. 34, issue 1, 54-62

Abstract: Conditions for the validity of the Hoel‐Walburg and Peto tests, which compare dose groups with respect to tumour prevalence, are replaced by a more general condition, representativeness. A large carcinogenicity experiment provided a unique opportunity to assess empirically if this condition holds. Though representativeness was generally violated, neither the Hoel–Walburg nor the Peto tests were seriously distorted. Analytic considerations suggest that such robustness can occur in many situations.

Date: 1985
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