 Estimating Carcinogenic Potency from a Rodent Tumorigenicity ExperimentDianne M. Finkelstein and Louise M. Ryan Journal of the Royal Statistical Society Series C, 1987, vol. 36, issue 2, 121-133 Abstract: Rodent tumorigenicity experiments are conducted to determine whether a particular substance accelerates tumour development. The association between exposure to this substance and the risk of tumour development can be characterized by a measure of carcinogenic potency. The most commonly used potency measure, the dose effect on the lifetime risk of tumour, may be seriously biased, especially when control and exposed groups differ with respect to longevity. However, more appropriate measures, which account for age at death, are largely unavailable except in the special cases of instantly lethal or nonlethal tumours or tumours with observable onset. In this paper, we propose an estimate of carcinogenic potency based on a proportonal prevalence odds model which applies regardless of tumour lethality and can be calculated using standard statistical methodologies. Furthermore, we show how our estimator can be used to generalize available potency estimators to tumours of any lethality. Date: 1987 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:bla:jorssc:v:36:y:1987:i:2:p:121-133 Ordering information: This journal article can be ordered from Access Statistics for this article Journal of the Royal Statistical Society Series C is currently edited by R. Chandler and P. W. F. Smith More articles in Journal of the Royal Statistical Society Series C from Royal Statistical Society Contact information at EDIRC. |
Is your work missing from RePEc? Here is how to contribute.
Questions or problems? Check the EconPapers FAQ or send mail to .
EconPapers is hosted by the
School of Business at Örebro University.