Analysis of Dose–Response Data in the Presence of Extrabinomial Variation

Dennis D. Boos

Journal of the Royal Statistical Society Series C, 1993, vol. 42, issue 1, 173-183

Abstract: Binary dose–response data often exhibit extrabinomial variation when the responses arise naturally in groups or litters. This paper investigates the use of generalized Wald and score statistics for robustifying the standard inference methods based on the binomial likelihood. Special attention is given to the probit analysis of a parallel assay of the teratogenic effects on mice of several dioxins.

Date: 1993
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Persistent link: https://EconPapers.repec.org/RePEc:bla:jorssc:v:42:y:1993:i:1:p:173-183

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