The Effect of Drop‐Out on the Efficiency of Longitudinal Experiments

Geert Verbeke and Emmanuel Lesaffre

Journal of the Royal Statistical Society Series C, 1999, vol. 48, issue 3, 363-375

Abstract: It is shown that drop‐out often reduces the efficiency of longitudinal experiments considerably. In the framework of linear mixed models, a general, computationally simple method is provided, for designing longitudinal studies when drop‐out is to be expected, such that there is little risk of large losses of efficiency due to the missing data. All the results are extensively illustrated using data from a randomized experiment with rats.

Date: 1999
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