Incorporation of historical controls using semiparametric mixed models

Helen Parise, M. P. Wand, David Ruppert and Louise Ryan

Journal of the Royal Statistical Society Series C, 2001, vol. 50, issue 1, 31-42

Abstract: The analysis of animal carcinogenicity data is complicated by various statistical issues. A topic of recent debate is how to control for the effect of the animal's body weight on the outcome of interest, the onset of tumours. We propose a method which incorporates historical information from the control animals in previously conducted experiments. We allow non‐linearity in the effects of body weight by modelling the relationship nonparametrically through a penalized spline. A simple extension of the penalized spline model allows the relationship between weight and the onset of tumour to vary from one experiment to another.

Date: 2001
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https://doi.org/10.1111/1467-9876.00218

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Persistent link: https://EconPapers.repec.org/RePEc:bla:jorssc:v:50:y:2001:i:1:p:31-42

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