Analysis of interval‐censored data from clustered multistate processes: application to joint damage in psoriatic arthritis

Rinku Sutradhar and Richard J. Cook

Journal of the Royal Statistical Society Series C, 2008, vol. 57, issue 5, 553-566

Abstract: Summary. A conditionally Markov multiplicative intensity model is described for the analysis of clustered progressive multistate processes under intermittent observation. The model is motivated by a long‐term prospective study of patients with psoriatic arthritis with the aim of characterizing progression of joint damage via an irreversible four‐state model. The model accommodates heterogeneity in transition rates between different individuals and correlation in transition rates within patients. To do this we introduce subject‐specific multivariate random effects in which each component acts multiplicatively on a specific transition intensity. Through the association between the components of the random effect, correlations in transition intensities are accommodated. A Monte Carlo EM algorithm is developed for estimation, which features closed form expressions for estimators at each M‐step.

Date: 2008
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