Comparison of Within‐Subject Covariance Matrices in 2 × 2 Crossover Trials with Multivariate Response

Niclas Sjögren and Olivier Guilbaud

Scandinavian Journal of Statistics, 2004, vol. 31, issue 4, 603-612

Abstract: Abstract. In a multivariate framework, it is shown how the two treatments in a 2 × 2 crossover trial with multivariate response can be compared with respect to mean vectors, i.e. fixed treatment effects, as well as within‐subject covariance matrices, marginally and simultaneously. No distributional assumption is made about the between‐subject variability, whereas multivariate normality is assumed for the within‐subject variability. The proposed exact statistical inferences are valid even with few subjects. Data from a crossover trial with bivariate response are analysed with the proposed multivariate methods as well as with univariate methods.

Date: 2004
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https://doi.org/10.1111/j.1467-9469.2004.00409.x

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Persistent link: https://EconPapers.repec.org/RePEc:bla:scjsta:v:31:y:2004:i:4:p:603-612

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