Non‐parametric Estimation of a Survival Function with Two‐stage Design Studies

Gang Li and Chi‐hong Tseng

Scandinavian Journal of Statistics, 2008, vol. 35, issue 2, 193-211

Abstract: Abstract. The two‐stage design is popular in epidemiology studies and clinical trials due to its cost effectiveness. Typically, the first stage sample contains cheaper and possibly biased information, while the second stage validation sample consists of a subset of subjects with accurate and complete information. In this paper, we study estimation of a survival function with right‐censored survival data from a two‐stage design. A non‐parametric estimator is derived by combining data from both stages. We also study its large sample properties and derive pointwise and simultaneous confidence intervals for the survival function. The proposed estimator effectively reduces the variance and finite‐sample bias of the Kaplan–Meier estimator solely based on the second stage validation sample. Finally, we apply our method to a real data set from a medical device postmarketing surveillance study.

Date: 2008
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https://doi.org/10.1111/j.1467-9469.2007.00581.x

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Persistent link: https://EconPapers.repec.org/RePEc:bla:scjsta:v:35:y:2008:i:2:p:193-211

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