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Group Tests for High-dimensional Failure Time Data with the Additive Hazards Models

Jiang Dandan and Sun Jianguo ()
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Jiang Dandan: Center for Applied Statistical Research, School of Mathematics, Jilin University, Changchun, China
Sun Jianguo: Center for Applied Statistical Research, School of Mathematics, Jilin University, Changchun, China; Department of Statistics, University of Missouri, Missouri, USA

The International Journal of Biostatistics, 2017, vol. 13, issue 1, 10

Abstract: Statistical analysis of high-dimensional data has been attracting more and more attention due to the abundance of such data in various fields such as genetic studies or genomics and the existence of many interesting topics. Among them, one is the identification of a gene or genes that have significant effects on the occurrence of or are significantly related to a certain disease. In this paper, we will discuss such a problem that can be formulated as a group test or testing a group of variables or coefficients when one faces right-censored failure time response variable. For the problem, we develop a corrected variance reduced partial profiling (CVRPP) linear regression model and a likelihood ratio test procedure when the failure time of interest follows the additive hazards model. The numerical study suggests that the proposed method works well in practical situations and gives better performance than the existing one. An illustrative example is provided.

Keywords: additive hazards model; group tests; high-dimensional data (search for similar items in EconPapers)
Date: 2017
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