The Youden Index in the Generalized Receiver Operating Characteristic Curve Context

Martínez-Camblor Pablo () and Pardo-Fernández Juan Carlos
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Martínez-Camblor Pablo: The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth College, 7 Lebanon Street, Suite 309, Hinman Box 7251, Hanover, NH 03755, USA
Pardo-Fernández Juan Carlos: Department of Statistics and OR, and Biomedical Research Centre, Universidade de Vigo, Vigo, Spain

The International Journal of Biostatistics, 2019, vol. 15, issue 1, 20

Abstract: The receiver operating characteristic (ROC) curve and their associated summary indices, such as the Youden index, are statistical tools commonly used to analyze the discrimination ability of a (bio)marker to distinguish between two populations. This paper presents the concept of Youden index in the context of the generalized ROC (gROC) curve for non-monotone relationships. The interval estimation of the Youden index and the associated cutoff points in a parametric (binormal) and a non-parametric setting is considered. Monte Carlo simulations and a real-world application illustrate the proposed methodology.

Keywords: (Bio)markers; cutoff point; generalized receiver-operating characteristic (gROC) curve; receiver-operating characteristic (ROC) curve; Youden index (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:bpj:ijbist:v:15:y:2019:i:1:p:20:n:6

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DOI: 10.1515/ijb-2018-0060

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