Comparison of Estimators for Measures of Linkage Disequilibrium

Scholz Markus and Hasenclever Dirk
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Scholz Markus: University of Leipzig
Hasenclever Dirk: University of Leipzig

The International Journal of Biostatistics, 2010, vol. 6, issue 1, 14

Abstract: The measurement of biallelic pair-wise association called linkage disequilibrium (LD) is an important issue in order to understand the genomic architecture. A plethora of measures of association in two by two tables have been proposed in the literature. Beside the problem of choosing an appropriate measure, the problem of their estimation has been neglected in the literature. It needs to be emphasized that the definition of a measure and the choice of an estimator function for it are conceptually unrelated tasks.In this paper, we compare the performance of various estimators for the three popular LD measures D', r and Y in a simulation study for small to moderate samples sizes (N

Keywords: measures of linkage disequilibrium; two by two contingency tables; estimation problem; Dirichlet prior (search for similar items in EconPapers)
Date: 2010
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DOI: 10.2202/1557-4679.1162

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