Mutagenic effects of selected trichothecene mycotoxins and their combinations with aflatoxin B1

P. Šmerák, I. Bárta, Z. Polívková, J. Bártová and M. Sedmíková
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P. Šmerák: 3rd Medical Faculty, Charles University, Prague; Czech Agricultural University, Prague, Czech Republic
I. Bárta: 3rd Medical Faculty, Charles University, Prague; Czech Agricultural University, Prague, Czech Republic
Z. Polívková: 3rd Medical Faculty, Charles University, Prague; Czech Agricultural University, Prague, Czech Republic
J. Bártová: 3rd Medical Faculty, Charles University, Prague; Czech Agricultural University, Prague, Czech Republic
M. Sedmíková: 3rd Medical Faculty, Charles University, Prague; Czech Agricultural University, Prague, Czech Republic

Czech Journal of Food Sciences, 2001, vol. 19, issue 3, 90-96

Abstract: The authors focused on the amplification of data on the mutagenicity of selected trichothecene mycotoxins (T-2 toxin, vomitoxin) and their combination with aflatoxin B1,which is known to be a strong mutagen. Mutagenic activity was investigated using the Ames test in a prokaryote model at low doses (close to 0.1 LD50). Whereas the individual trichothecene mycotoxins (T-2 toxin, vomitoxin) did not show any mutagenic activity in the test systems mentioned, in combination with AFB1, or as a combination of all three mycotoxins, they showed a mutagenic effect significantly greater than AFB1 alone in the Ames test (in strain TA98 at all concentrations) as well as in the micronucleus test (combination of T-2 toxin with AFB1).

Keywords: mutagenic activity; Ames test; micronucleus test; mycotoxins; aflatoxin B1; T-2 toxin; vomitoxin (search for similar items in EconPapers)
Date: 2001
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjf:v:19:y:2001:i:3:id:6583-cjfs

DOI: 10.17221/6583-CJFS

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