Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young men

V. Šimánek, N. Škottová, J. Bartek, J. Psotová, P. Kosina, L. Balejová and J. Ulrichová
Additional contact information
V. Šimánek: 1 LIBUŠE BALEJOVÁ and JITKA ULRICHOVÁ
N. Škottová: 1 LIBUŠE BALEJOVÁ and JITKA ULRICHOVÁ
J. Bartek: 1 LIBUŠE BALEJOVÁ and JITKA ULRICHOVÁ
J. Psotová: 1 LIBUŠE BALEJOVÁ and JITKA ULRICHOVÁ
P. Kosina: 1 LIBUŠE BALEJOVÁ and JITKA ULRICHOVÁ
L. Balejová: 1 LIBUŠE BALEJOVÁ and JITKA ULRICHOVÁ
J. Ulrichová: 1 LIBUŠE BALEJOVÁ and JITKA ULRICHOVÁ

Czech Journal of Food Sciences, 2001, vol. 19, issue 3, 106-110

Abstract: In a randomized, double-blind, placebo-controlled study, the effect of an extract from Silybum marianum seeds (ESM, milk thistle extract) on lipid and liver parameters and the antioxidant capacity of serum was investigated in 29 healthy men aged 18-32 years. They received either 858 mg of ESM (531 mg silymarin complex calculated on pure silibinin), or placebo, daily for the period of 60 days. No side effects were found. A routine biochemical analysis of the serum was performed as a measure of lipid and liver metabolism. Positive trend towards decreased serum cholesterol level and HDL-cholesterol increase was observed in the ESM group as compared to the placebo group. The serum antioxidant capacity was significantly higher in the ESM group. The results suggest the use of ESM as a dietary supplement for hypercholesterolemia.

Keywords: Silybum marianum; silymarin complex; double-blind; randomised placebo-controlled study; cholesterol; HDL; antioxidant status; nutraceutical (search for similar items in EconPapers)
Date: 2001
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Citations: View citations in EconPapers (2)

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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjf:v:19:y:2001:i:3:id:6585-cjfs

DOI: 10.17221/6585-CJFS

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