Antimutagenic effect of resveratrol

Martina Langová, Zdeňka Polívková, Petr Šmerák, Jiřina Bártová and Ivo Bárta
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Martina Langová: Department of General Biology and Genetics, Center of Biomedical Science and
Zdeňka Polívková: Department of General Biology and Genetics, Center of Biomedical Science and
Petr Šmerák: Department of General Biology and Genetics, Center of Biomedical Science and
Jiřina Bártová: Department of General Hygiene, Center of Preventive Medicine, 3 rd Faculty of Medicine, Charles University, Prague, Czech Republic
Ivo Bárta: Department of General Biology and Genetics, Center of Biomedical Science and

Czech Journal of Food Sciences, 2005, vol. 23, issue 5, 202-208

Abstract: Evidence exists from population-based and laboratory studies that some phytochemicals have protective effects against tumors or other diseases and reveal antimutagenic activity. We studied the protective effect of the plant phytoallexin resveratrol on the mutagenic activity of three mutagens, i.e. aflatoxin B1 (AFB1), 2-amino-3-methylimidazo[4,5-f]qui-noline (IQ) and N-nitroso-N-methylurea (MNU) using the Ames and the micronucleus tests. In the Ames test, we proved a significant antimutagenic activity only against the indirect mutagens AFB1 and IQ, not against the direct mutagen MNU. A significant decrease of mutagenicity of all three mutagens was detected by the micronucleus test.

Keywords: resveratrol; aflatoxin B1; 2-amino-3-methylimidazo[4; 5-f]quinoline; N-nitroso-N-methylurea (search for similar items in EconPapers)
Date: 2005
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjf:v:23:y:2005:i:5:id:3392-cjfs

DOI: 10.17221/3392-CJFS

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