Chemoprotective Effects of Broccoli Juice Treated with High Pressure

Lucie Mandelová and Jiří Totušek
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Lucie Mandelová: Institute of Preventive Medicine, Faculty of Medicine, Masaryk University in Brno, Brno, Czech Republic
Jiří Totušek: Institute of Preventive Medicine, Faculty of Medicine, Masaryk University in Brno, Brno, Czech Republic

Czech Journal of Food Sciences, 2006, vol. 24, issue 1, 19-25

Abstract: We investigated chemoprotective effects of broccoli juice, treated with high pressure method, using 500 MPa for a period of 10 minutes. By the use of this method, the conservation of nutritionally important substances occurs (for example vitamins, polyphenolic compounds, glucosinolates and other constituent substances). We followed the inhibition of mutagenicity of the model mutagen, N-nitroso-N-methylurea (MNU), by means of in vivo micronucleus test. After fourteen-day application of broccoli juice (0.2 ml/10 g of body weight of mouse) and after a single administration of MNU mutagen (50 mg/kg), a statistically significant decrease (p < 0.01) occurred of the number of micronuclei induced by the application of MNU. Broccoli juice treated with high pressure therefore seems to have a preventive potential against MNU-induced micronuclei formation in BALB/C mouse bone marrow cells.

Keywords: micronucleus test; broccoli; antimutagenicity; MNU (search for similar items in EconPapers)
Date: 2006
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjf:v:24:y:2006:i:1:id:3289-cjfs

DOI: 10.17221/3289-CJFS

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