Antimutagenic effect of curcumin and its effect on the immune response in mice

Petr Šmerák, Zdeňka Polívková, Helena Šestáková, Rudolf Štětina, Ivo Bárta, Martina Langová, Bohumil Turek and Jiřina Bártová
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Petr Šmerák: Department of General Biology and Genetics and 4Department of General Hygiene, Center of Biomedical Science, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
Zdeňka Polívková: Department of General Biology and Genetics and 4Department of General Hygiene, Center of Biomedical Science, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
Helena Šestáková: National Institute of Public Health, Prague, Czech Republic
Rudolf Štětina: Faculty of Military Health Sciences, Department of Toxicology, Hradec Kralové, Czech Republic
Ivo Bárta: Department of General Biology and Genetics and 4Department of General Hygiene, Center of Biomedical Science, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
Martina Langová: Department of General Biology and Genetics and 4Department of General Hygiene, Center of Biomedical Science, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
Bohumil Turek: National Institute of Public Health, Prague, Czech Republic

Czech Journal of Food Sciences, 2006, vol. 24, issue 2, 72-83

Abstract: A wide array of antioxidative and anti-inflammatory substances derived from edible plants have been reported to possess chemopreventive and chemoprotective activities. Among the most extensively investigated and well-defined dietary chemopreventives is curcumin. Using the Ames test and in vivo micronucleus test, chemiluminescence test, blastic transformation test, and comet assay, we examined the antimutagenic effects of the chemically identified chemoprotective substance curcumin (diferuloylmethane) in the pure form on mutagenicity induced by three reference mutagens: aflatoxin B1 (AFB1), 2-amino-3-metylimidazo[4,5-f]quinoline (IQ), and N-nitroso-N-metylurea (MNU), and the effect of curcumin on the immunosuppression caused by these mutagens. Curcumin in the pure form showed a clear antimutagenic and immunomodulatory activities on mutagenicity and immunosuppression induced by reference mutagens.

Keywords: curcumin; antimutagenic effects; response of immune; Ames test; micronucleus test; comet assay; chemiluminescence; blastic transformation tests (search for similar items in EconPapers)
Date: 2006
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Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjf:v:24:y:2006:i:2:id:3302-cjfs

DOI: 10.17221/3302-CJFS

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Czech Journal of Food Sciences is currently edited by Ing. Zdeňka Náglová, Ph.D.

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