Tissue distribution and elimination of florfenicol in topmouth culter (Culter alburnus) after oral administration

Weifen Wang, Xianjun Dai, Zhiqiang Li and Qingli Meng
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Weifen Wang: College of Life Science, China Jiliang University, Hangzhou, Zhejiang Province, China
Xianjun Dai: College of Life Science, China Jiliang University, Hangzhou, Zhejiang Province, China
Zhiqiang Li: Xiaoshan School of Science and Technology, Zhejiang Ocean University, Hangzhou, Zhejiang Province, China
Qingli Meng: College of Life Science, China Jiliang University, Hangzhou, Zhejiang Province, China

Czech Journal of Food Sciences, 2009, vol. 27, issue 3, 214-221

Abstract: The serum concentration and muscle residue of florfenicol following oral administration were evaluated in topmouth culter (Culter alburnus) under field conditions. Fishes were cultured in tanks and fed a commercial medicated diet containing 2000 mg/kg florfenicol in a single dose. The sampling was conducted at different intervals (0, 0.5, 1, 1.5, 2, 3, 4, 8, 10, 12, 16, 24, 36, 48, 72, 96, 120, 144, 168 h) after the cessation of medication. Drug analysis was carried out by HPLC. The maximum concentration (Cmax) of 10.8 μg/g in serum and 4.2 μg/g in muscle were reached at the same time (tmax) of 8 hours. If the EU MRL value of 1.0 μg/g is quoted for the topmouth culter tissue, the extrapolation of the data indicated that it will be passed after a 40.6 h withdrawal period for florfenicol in topmouth culter muscle.

Keywords: serum; elimination; florfenicol; topmouth culter (Culter alburnus) (search for similar items in EconPapers)
Date: 2009
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjf:v:27:y:2009:i:3:id:183-2008-cjfs

DOI: 10.17221/183/2008-CJFS

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