Anticancer Activity of Lignan from the Aerial Parts of Saussurea salicifolia (L.) DC

G. Chunsriimyatav, I. Hoza, P. Valášek, S. Skrovanková, D. Banzragch and N. Tsevegsuren
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G. Chunsriimyatav: Department of Food Engineering, Tomas Bata University in Zlin, 760 01 Zlín, Czech Republic
I. Hoza: Department of Food Engineering, Tomas Bata University in Zlin, 760 01 Zlín, Czech Republic
P. Valášek: Department of Food Engineering, Tomas Bata University in Zlin, 760 01 Zlín, Czech Republic
S. Skrovanková: Department of Food Engineering, Tomas Bata University in Zlin, 760 01 Zlín, Czech Republic
D. Banzragch: Institute of Chemistry and Chemical Technology, Mongolian Academy Sciences, Ulaanbaatar, MON 51 Mongolia
N. Tsevegsuren: Department of Organic Chemistry, Faculty of Chemistry, National University of Mongolia, Ulaanbaatar, Mongolia, *E-mail: chunsrii82@yahoo.com$2

Czech Journal of Food Sciences, 2009, vol. 27, issue SpecialIssue1, S256-S258

Abstract: Aerial parts of Saussurea salicifolia (L.) DC were studied for their lignan and flavonoids in solvent chloroform and n-butanol of ethanolic extract. Isolation and identification of phenolic compounds of the chloroform and n-butanol fractions were performed with Dionex HPLC-DAD system with water-methanol gradients in 4 different wave lengths (235 nm, 254 nm, 280 nm and 340 nm), using online UV and LC-MS as described previously. 9-OH-pinoresinol which is a lignan with anticancer activity was dominated in the chloroform fraction, whereas mainly flavonoid glycosides like quercetin-3-O-galactoside, apigenin-7-O-rhamnoside with anti-inflammatory effect were detected in the n-butanol fraction. Additionally, 9-OH-pinoresinol was also found in the n-butanol fraction. Anticancer tests were conducted in leukemia mouse lymphoma cells L5178Y at a concentration of 10 μg/ml of test compound. Crude ethanol extract of S. salicifolia reduced the growth of leukemia mouse lymphoma cells L5178Y to 23.8%.

Keywords: flavonoids; Saussurea salicifolia; anticancer activity; Dionex HPLC-DAD system (search for similar items in EconPapers)
Date: 2009
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjf:v:27:y:2009:i:specialissue1:id:1097-cjfs

DOI: 10.17221/1097-CJFS

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