Details of the antioxidant mechanism of hydroxycinnamic acids

Ya-Jing Shang, Bao-Yong Liu and Meng-Meng Zhao
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Ya-Jing Shang: School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, P.R. China
Bao-Yong Liu: School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, P.R. China
Meng-Meng Zhao: School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, P.R. China

Czech Journal of Food Sciences, 2015, vol. 33, issue 3, 210-216

Abstract: Antioxidant activities and free radical-mediated DNA strand breakages of five hydroxycinnamic acids were examined. Kinetic analysis of a stable galvinoxy (GO*)-scavenging reaction of hydroxycinnamic acids demonstrated that the molecular structure and the reaction medium were two important factors affecting the antioxidant mechanism and activity. In methanol, the kinetic process of the compounds, which have electron-donating groups (-OH, -OCH3) in the ortho- or para-position of 4-OH, was primarily governed by the sequential proton loss electron transfer (SPLET mechanism). While, in ethyl acetate, the reaction mechanism is predominantly direct hydrogen atom transfer (HAT mechanism). But for the compounds having only one hydroxyl, both in ethyl acetate and methanol, the reaction mechanism is only HAT. At the same time, the compound bearing o-diphenoxyl is not the most active one in our tested environment.

Keywords: radical-scavenging activity; DNA strand breakage; reaction mechanisms structure-activity relationship (search for similar items in EconPapers)
Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjf:v:33:y:2015:i:3:id:611-2014-cjfs

DOI: 10.17221/611/2014-CJFS

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