Determination of trans-resveratrol action on two different types of neuronal cells, neuroblastoma and hippocampal cells

Joanna Gerszon and Aleksandra Rodacka
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Joanna Gerszon: Department of Molecular Biophysics, Institute of Biophysics, University of Lodz, Lodz, Poland
Aleksandra Rodacka: Department of Molecular Biophysics, Institute of Biophysics, University of Lodz, Lodz, Poland

Czech Journal of Food Sciences, 2016, vol. 34, issue 2, 118-126

Abstract: The effects of resveratrol on a cancer cell line derived from the nervous system, neuroblastoma and a cell line derived from hippocampal neurons under hydrogen peroxide-induced oxidative stress were evaluated and compared. Our studies indicate that resveratrol exerts different effects on tumour and normal cells. Interestingly, in the presence of an oxidising factor resveratrol can sensitise cancer cells and decrease their viability substantially. Under conditions of oxidative stress similar to those found in the tumour environment, resveratrol also intensified apoptosis in Neuro-2a cells. Our data indicate that resveratrol does not protect neuronal, hippocampal cells from oxidative damage.

Keywords: cancer; oxidative stress; polyphenol; stillbenoid (search for similar items in EconPapers)
Date: 2016
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