Curcumin and its allied analogues: epigenetic and health perspectives - a review

Muhammad Imran, Muhammad Nadeem, Muhammad Asif Khan, Sheraz Ahmed, Ali Imran, Rai Muhammad Amir, Muhammad Umair Arshad, Syed Amir Gilani, Farhan Saeed, Abdur Rauf, Zaffar Mehmood, Shaista Khan and Hafiz Ansar Rasul Suleria
Additional contact information
Muhammad Imran: Department of Diet and Nutritional Sciences, Imperial College of Business Studies, Lahore, Pakistan
Muhammad Nadeem: Department of Environmental Sciences, CoMsaTs Institute of Information Technology, Vehari, Pakistan
Muhammad Asif Khan: University of Agriculture, Faisalabad-sub Campus Burewala/Vehari, Pakistan
Sheraz Ahmed: Department of Food Science and Technology, Islamia University of Bhawalpur, Bhawalpur, Pakistan
Ali Imran: Faculty of Home and Food Sciences, Government College University, Faisalabad, Pakistan
Rai Muhammad Amir: Institute of Food and Nutritional Sciences, Pmas-Arid Agriculture University, Rawalpindi, Pakistan
Muhammad Umair Arshad: Faculty of Home and Food Sciences, Government College University, Faisalabad, Pakistan
Syed Amir Gilani: Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan
Farhan Saeed: Faculty of Home and Food Sciences, Government College University, Faisalabad, Pakistan
Abdur Rauf: Department of Chemistry, University of Swabi, Ankbar Swabi, Pakistan
Zaffar Mehmood: Department of Biological Sciences, Forman Christian College, Lahore, Pakistan

Czech Journal of Food Sciences, 2017, vol. 35, issue 4, 285-310

Abstract: Curcumin (diferuoyl methane) is a yellow active ingredient present in turmeric. It is a homodimer of feruloylmethane that comprises a hydroxyl and methoxy group (heptadiene with two Michael acceptors), and α-, β-diketone. It contains various metabolites, i.e. hexahydrocurcumin (HHC), tetrahydrocurcumin (THC), octahydrocurcumin (OHC), dihydrocurcumin (DHC), curcumin sulphate, and curcumin glucuronide. Curcumin has been proven the most effective histone deacetylase (HDAC) inhibitor in HeLa nuclear extracts. It has the ability to affect the Akt, growth factors, NF-kB, and metastatic and angiogenic pathways. Curcumin has a strong therapeutic or preventive potential against several major human ailments, i.e. suppression of inflammation, cardiovascular, diabetes, tumorigenesis, chronic fatigue, antidepressant and neurological activities, depression, loss of muscle and bone, and neuropathic pain. In future, higher utilisation of curcumin as an active agent in food based products is required to curtail the human health disorders.

Keywords: turmeric; chemistry and metabolism; epigenetic role; anticancer; low toxicity (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjf:v:35:y:2017:i:4:id:584-2015-cjfs

DOI: 10.17221/584/2015-CJFS

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