Sex reversed chicks (Gallus domesticus) hatched from eggs treated with aromatase inhibitor YM511

P. Trefil, A. Mičáková, J. Mucksová, M. Poplštein, J.-P. Brillard and P. Hodek
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P. Trefil: BIOPHARM, Research Institute of Biopharmacy and Veterinary Drugs, Jílové near Prague, Czech Republic
A. Mičáková: BIOPHARM, Research Institute of Biopharmacy and Veterinary Drugs, Jílové near Prague, Czech Republic
J. Mucksová: BIOPHARM, Research Institute of Biopharmacy and Veterinary Drugs, Jílové near Prague, Czech Republic
M. Poplštein: BIOPHARM, Research Institute of Biopharmacy and Veterinary Drugs, Jílové near Prague, Czech Republic
J.-P. Brillard: INRA, Centre de Tours-Nouzilly, Station de Recherches Avicoles, Nouzilly, France
P. Hodek: Department of Biochemistry, Charles University, Prague, Czech Republic

Czech Journal of Animal Science, 2004, vol. 49, issue 12, 511-516

Abstract: The objectives of this study were to assess post-hatch development of chickens treated in ovo with the aromatase inhibitor YM511. A total of 137 eggs coming from artificially inseminated hens were at first injected in the albumen with either DMSO alone (54 eggs injected, control group) or with DMSO + aromatase inhibitor (YM511, 1 mg/egg, 83 eggs injected, treated group) and then incubated under standard conditions. Out of the 24 chicks hatched in the treated group, 16 were genetic males (ZZ) and 8 were genetic females (ZW). By 26 weeks of age, secondary sex characteristics of females (cloaca, comb, wattles, song, feathers of hackle and tail) progressively transformed into a male phenotype. Using CT-scanner technology in these 8 birds, the presence of irregular testis-like masses positioned in the antero-ventral portion of the kidneys was observable, an indication that reproductive organs had also been affected by the treatment.

Keywords: aromatase; inhibitor; sex reversal; chicken (search for similar items in EconPapers)
Date: 2004
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjs:v:49:y:2004:i:12:id:4338-cjas

DOI: 10.17221/4338-CJAS

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