Estimation of genetic parameters for melanoma in the Old Kladruber horse

L. Vostrý, B. Hofmanová, H. Vostrá Vydrová, J. Přibyl and I. Majzlík
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L. Vostrý: Faculty of Agrobiology, Food and Nature Resources, Czech University of Life Sciences, Prague, Czech Republic
B. Hofmanová: Faculty of Agrobiology, Food and Nature Resources, Czech University of Life Sciences, Prague, Czech Republic
H. Vostrá Vydrová: Faculty of Economics and Management, Czech University of Life Sciences, Prague, Czech Republic
J. Přibyl: Institute of Animal Science, Prague-Uhříněves, Czech Republic
I. Majzlík: Faculty of Agrobiology, Food and Nature Resources, Czech University of Life Sciences, Prague, Czech Republic

Czech Journal of Animal Science, 2012, vol. 57, issue 2, 75-82

Abstract: The aim of this study was to assess the prevalence of melanoma to investigate a possible genetic variation of this trait in the Old Kladruber horse. A total of 564 grey varieties of the Old Kladruber horse, 238 males and 326 females, with five generations of ancestors (n = 1245 animals) were analysed. Melanoma status was recorded for different stages. Three different analyses were conducted: a linear animal model (LM) with melanoma classified into five categories, threshold animal model (TM) with melanoma classified into five categories and threshold animal model (TMb) with melanoma classified into two categories (0 = absence, 1 = presence). All models included the fixed effects of year of evaluation, age, line, sex, greying level, random direct genetic effect, and the effect of animal's permanent environment. Heritability for melanoma occurrence was estimated for LM - 0.09, for TM - 0.27, and for TMb - 0.11. The coefficient of repeatability was estimated for LM - 0.77, for TM - 0.90, and for TMb - 0.99. The values of the Pearson's correlation coefficient and Spearmen's rank correlation coefficient among breeding values estimated by LM, TM, and TMb models were from 0.82 to 0.88 and from 0.83 to 0.90, respectively, for data with pedigree information and from 0.77 to 0.84 and 0.77 to 0.88, respectively, for a subset of animals with measurements. Results suggest that additive genetic variation of melanoma occurrence in the Old Kladruber horse seems large enough to be exploited in a specific breeding programme.

Keywords: melanoma; linear model; threshold model; horse; heritability; breeding value (search for similar items in EconPapers)
Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjs:v:57:y:2012:i:2:id:5134-cjas

DOI: 10.17221/5134-CJAS

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