Bovine hemoglobin polymorphism: a novel alpha-globin variant identified in the Agerolese breed from southern Italy

A.M. Salzano, A. Pauciullo, C. D'Ambrosio, G. Novi, M. Strazzullo and A. Scaloni
Additional contact information
A.M. Salzano: Institute for the Animal Production System in the Mediterranean Environment, National Research Council (CNR), Napoli, Italy
A. Pauciullo: Institute for the Animal Production System in the Mediterranean Environment, National Research Council (CNR), Napoli, Italy
C. D'Ambrosio: Institute for the Animal Production System in the Mediterranean Environment, National Research Council (CNR), Napoli, Italy
G. Novi: Institute for the Animal Production System in the Mediterranean Environment, National Research Council (CNR), Napoli, Italy
M. Strazzullo: Institute for the Animal Production System in the Mediterranean Environment, National Research Council (CNR), Napoli, Italy
A. Scaloni: Institute for the Animal Production System in the Mediterranean Environment, National Research Council (CNR), Napoli, Italy

Czech Journal of Animal Science, 2015, vol. 60, issue 4, 145-151

Abstract: This study describes the results of molecular screening in the Agerolese cattle breed from southern Italy, which constitutes an economical source and contributes to the regional biodiversity. Integrated electrophoretic, chromatographic, mass spectrometric, and DNA sequencing procedures were used to qualitatively and quantitatively evaluate globin chain polymorphism in a population of animals from different farms. In addition to α-, βA-, and βB-globin-bearing animal phenotypes, our data demonstrate the occurrence of individuals characterized by the presence of a novel α-globin variant, whose primary structure differs from the normal counterpart for the p.Ala27Thr substitution. The SNP c.79G>A located at the exon 1 of the HBA2 gene is responsible for this amino acid change and it represents a third example of α-globin gene polymorphism observed in Bos taurus. This phenomenon was ascertained only in two Mediterranean breeds from southern Italy and highlights the uncommon occurrence of α-globin variants in this geographical region, similarly to what has already been described in goat and human.

Keywords: Bos taurus; native cattle breed; amino acid substitution; HBA2 gene; SNP (search for similar items in EconPapers)
Date: 2015
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
http://cjas.agriculturejournals.cz/doi/10.17221/8128-CJAS.html (text/html)
http://cjas.agriculturejournals.cz/doi/10.17221/8128-CJAS.pdf (application/pdf)
free of charge

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjs:v:60:y:2015:i:4:id:8128-cjas

DOI: 10.17221/8128-CJAS

Access Statistics for this article

Czech Journal of Animal Science is currently edited by Bc. Michaela Polcarová

More articles in Czech Journal of Animal Science from Czech Academy of Agricultural Sciences
Bibliographic data for series maintained by Ivo Andrle ().