Effects of zearalenone, α-zearalenol, and genistein on boar sperm motility in vitro

Adéla Krejcárková, Petra Folková, Ondřej Šimoník, Martina Šašková, Romana Krejčířová, Ondřej Drábek and Radko Rajmon
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Adéla Krejcárková: Department of Veterinary Sciences, Faculty of Agriculture, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, Czech Republic
Petra Folková: Department of Veterinary Sciences, Faculty of Agriculture, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, Czech Republic
Ondřej Šimoník: Department of Veterinary Sciences, Faculty of Agriculture, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, Czech Republic
Martina Šašková: Department of Veterinary Sciences, Faculty of Agriculture, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, Czech Republic
Romana Krejčířová: Department of Veterinary Sciences, Faculty of Agriculture, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, Czech Republic
Ondřej Drábek: Department of Soil Science and Soil Protection, Faculty of Agriculture, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, Czech Republic
Radko Rajmon: Department of Veterinary Sciences, Faculty of Agriculture, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, Czech Republic

Czech Journal of Animal Science, 2017, vol. 62, issue 10, 435-445

Abstract: Genistein (GEN) and zearalenone (ZEA), environmental oestrogens commonly present in feedstuff for pigs, are known for their effects on reproductive functions. The aim was to verify the in vitro effects of 0.5-20 µM concentrations of GEN, ZEA and its metabolite α-zearalenol (α-ZOL) on pig sperm motility. A dose-dependent increase of the immotile sperm amount against fast and medium-fast sperm clusters was observed with all three oestrogens from the lowest concentrations tested. Individual CASA (computer-assisted sperm analysis) parameters of motile sperms seemed to be less sensitive indicators. This should be considered especially in toxicological research on a sperm model. Background of inconsistencies in to date-published papers is discussed. The results shift the effective concentrations of ZEA, α-ZOL, and GEN to values achievable in vivo and raises the questions of risk assessment of these compounds in pig reproduction.

Keywords: pig; spermatozoa; environmental oestrogens; motility; CASA; cluster analysis (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjs:v:62:y:2017:i:10:id:19-2017-cjas

DOI: 10.17221/19/2017-CJAS

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