Two single nucleotide polymorphisms in the caprine GnIH gene are associated with litter size

Xiaopeng An, Lijuan Bao, Jinxing Hou, Yueyu Bai, Xinyan Zhao, Yuxuan Song and Binyun Cao
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Xiaopeng An: College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China
Lijuan Bao: College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China
Jinxing Hou: College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China
Yueyu Bai: Animal Health Supervision Institute of Henan Province, Zhengzhou, P.R. China
Xinyan Zhao: Northwest A&F University of Hospital, Northwest A&F University, Yangling, P.R. China
Yuxuan Song: College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China
Binyun Cao: College of Animal Science and Technology, Northwest A&F University, Yangling, P.R. China

Czech Journal of Animal Science, 2017, vol. 62, issue 7, 269-275

Abstract: Gonadotropin-inhibitory hormone (GnIH) can decrease luteinizing hormone and/or follicle-stimulating hormone levels in rat, mouse, sheep, and cattle by the direct suppression of gonadotropin-releasing hormone (GnRH). The present study investigated polymorphisms in the GnIH genes of two dairy goat breeds and their association with litter size. Single nucleotide polymorphisms (SNPs) g.1837C>G and g.3195G>A (GenBank Accession Nos. KR778885 and KR819142) were detected in the GnIH genes of Xinong Saanen and Guanzhong dairy goat breeds using DNA sequencing and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Furthermore, the g.1837C>G and g.3195G>A loci were closely linked in both breeds (r2 > 0.33). Association analysis showed that these SNPs had significant effects on the litter size of goats (P < 0.05). In both breeds, individuals with the CC/GG (g.1837C>G/g.3195G>A) genotype showed larger litter sizes in the second and average parities than individuals with the GG/AA genotype (P < 0.05). Known biochemical and physiological functions, along with our results, indicate that the CC/GG genotype may be used in marker-assisted selection to choose individuals with a larger litter size from both breeds.

Keywords: PCR-RFLP; SNPs; combined genotype; candidate gene (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjs:v:62:y:2017:i:7:id:58-2016-cjas

DOI: 10.17221/58/2016-CJAS

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