Anti-diabetic effect of rice extract constituents through the molecular inhibition of α-amylase and α-glucosidase activity

Subhashini Ramakrishnan, Thomas Jebastin, Sumathy Raj, Ariyamuthu Ramathilaga, Rithik Selvaraj, Najat A. Bukhari A., Ashraf Atef Hatamleh and Anis Ahamed
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Subhashini Ramakrishnan: Department of Biotechnology, Dr. G.R. Damodaran College of Science, Coimbatore, Tamil Nadu, India
Thomas Jebastin: Computer Aided Drug Designing Lab, Department of Bioinformatics, Bishop Heber College (Autonomous), Tamil Nadu, India
Sumathy Raj: Department of Biotechnology, Dr. G.R. Damodaran College of Science, Coimbatore, Tamil Nadu, India
Ariyamuthu Ramathilaga: Department of Biotechnology, Dr. G.R. Damodaran College of Science, Coimbatore, Tamil Nadu, India
Rithik Selvaraj: Department of Biotechnology, Dr. G.R. Damodaran College of Science, Coimbatore, Tamil Nadu, India
Najat A. Bukhari A.: Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
Ashraf Atef Hatamleh: Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
Anis Ahamed: Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia

Plant, Soil and Environment, 2024, vol. 70, issue 11, 683-694

Abstract: Carbohydrate digestive enzymes like α-amylase and α-glucosidase can be used to treat and manage diabetes. By inhibiting these enzymes, carbohydrate digestion slowed down, lowering the level of glucose entry into the bloodstream and preventing postprandial hyperglycemia. However, the effectiveness of current antidiabetic agents is limited due to their adverse effects. Therefore, the current study explored natural inhibitors from the methanol extract of rice to combat this issue. Through an integrated approach, four different rice cultivars were analysed and found that red rice methanol extract compounds stigmasterol and 1,2-benzenedicarboxylic acid interacted with α-amylase and α-glucosidase. Additionally, further research on stigmasterol directs the structure-activity relationship studies that aid in managing diabetic conditions.

Keywords: Type2 Diabetes mellitus; hyperglycemic; carbohydrate hydrolysing enzymes; antioxidant activity; molecular interaction (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlpse:v:70:y:2024:i:11:id:150-2024-pse

DOI: 10.17221/150/2024-PSE

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