γδ-TCR+ CD2- lymphocytes are recruited into bovine mammary gland after stimulation

M. Faldyna, L. Leva, Z. Sladek, D. Rysanek and M. Toman
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M. Faldyna: Veterinary Research Institute, Brno, Czech Republic
L. Leva: Veterinary Research Institute, Brno, Czech Republic
Z. Sladek: Veterinary Research Institute, Brno, Czech Republic
D. Rysanek: Veterinary Research Institute, Brno, Czech Republic
M. Toman: Veterinary Research Institute, Brno, Czech Republic

Veterinární medicína, 2006, vol. 51, issue 5, 258-264

Abstract: γδ-T-Cell Receptor (TCR) lymphocytes were detected in mammary gland lavages collected from 10 clinically healthy virgin heifers before and after intramammary stimulation with synthetic muramyl dipeptide analogue. Using two-colour flow cytometry, CD2+ and CD2- subsets of γδ-TCR lymphocytes were analyzed. CD2+ γδ-TCR lymphocytes markedly prevailed over CD2- cells in intact mammary gland: 88.9 ± 4.9% of γδ-TCR lymphocytes were CD2+. After stimulation, neutrophils and γδ-TCR lymphocytes were recruited into the mammary gland. Among γδ-TCR lymphocytes, CD2- cells were mainly responsible for their expansion. After stimulation, 60.8 ± 13.4% of γδ-TCR lymphocytes were CD2+ (P < 0.01 when compared with mammary gland lavages before stimulation). It follows from the present study that the cells seem to be involved in the first phase of a response to an infection affecting mammary gland.

Keywords: cattle; udder; mastitis (search for similar items in EconPapers)
Date: 2006
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:51:y:2006:i:5:id:5545-vetmed

DOI: 10.17221/5545-VETMED

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