Progressive rod-cone degeneration (PRCD) in selected dog breeds and variability in its phenotypic expression

J. Dostal, A. Hrdlicova and P. Horak
Additional contact information
J. Dostal: Institution of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic
A. Hrdlicova: Institution of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic
P. Horak: Institution of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Libechov, Czech Republic

Veterinární medicína, 2011, vol. 56, issue 5, 243-247

Abstract: Progressive rod-cone degeneration (PRCD) is a late onset autosomal photoreceptor degeneration found in canines. PRCD in canines is homologous to one form of retinitis pigmentosa (RP) found in humans and displays phenotypic similarity as well as having the identical causative mutation. The PRCD gene was mapped to the centromeric region of canine chromosome 9 (CFA9). We report here a population study of 699 dogs of the following breeds and the following frequencies of the disease-causing mutation: American Cocker Spaniel (0.09), English Cocker Spaniel (0.34), English Springer Spaniel (0.00), Welsh Springer Spaniel (0.00), Flat Coated Retriever (0.00), Golden Retriever (0.00), Chesapeake Bay Retriever (0.14), Nova Scotia Duck Tolling Retriever (0.44), Labrador Retriever (0.07), Poodle Toy (0.45), Poodle Miniature (0.20), Poodle Medium (0.05), Poodle Standard (0.00), Portuguese Water Dog (0.33), Chinese Crested Dog (0.02), Shipperke (0.06), and Australian Cattle Dog (0.00). The disease results in complete blindness in the affected individual in almost every case. The time of onset and disease progression varies between dog breeds as well as between individuals. A modifier gene is likely to segregate in genomic proximity to the PRCD gene and may influence phenotypic expression.

Keywords: canine; retinitis pigmentosa; autosomal; recessive; causative mutation (search for similar items in EconPapers)
Date: 2011
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
http://vetmed.agriculturejournals.cz/doi/10.17221/1564-VETMED.html (text/html)
http://vetmed.agriculturejournals.cz/doi/10.17221/1564-VETMED.pdf (application/pdf)
free of charge

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:56:y:2011:i:5:id:1564-vetmed

DOI: 10.17221/1564-VETMED

Access Statistics for this article

Veterinární medicína is currently edited by Ing. Helena Smolová Ph.D.

More articles in Veterinární medicína from Czech Academy of Agricultural Sciences
Bibliographic data for series maintained by Ivo Andrle ().