Genetic basis of resistance to quaternary ammonium compounds - the qac genes and their role: a review

Z. Jaglic and D. Cervinkova
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Z. Jaglic: Veterinary Research Institute, Brno, Czech Republic
D. Cervinkova: Veterinary Research Institute, Brno, Czech Republic

Veterinární medicína, 2012, vol. 57, issue 6, 275-281

Abstract: Although the qac genes are named after one of their main substrates (i.e., quaternary ammonium compounds), these genes also code for resistance to a broad spectrum of other cationic compounds such as intercalating dyes, diamidines and biguanides. The various Qac proteins are involved in relatively low specific efflux-based multidrug pumps and belong to a family of small multidrug resistance proteins. Even though the practical significance of qac-mediated resistance lies mainly in resistance to antiseptics, contradictory findings on this issue are still reported. Therefore, the aim of this review is to summarise the current knowledge on qac-mediated resistance with special emphasis on resistance to antiseptics and its relevance for practice.

Keywords: antimicrobial; disinfectant; biocide; benzalkonium; chlorhexidine; cation; susceptibility (search for similar items in EconPapers)
Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:57:y:2012:i:6:id:6013-vetmed

DOI: 10.17221/6013-VETMED

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