Angiokeratoma with lysosomal dilatation in keratinocytes in a dog: a case report

H.K. Lim, H.J. Kim, H.R. Lee, S. Han and S.H. Do
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H.K. Lim: College of Veterinary Medicine and Veterinary Science Research Institute, Konkuk University, Seoul, Republic of Korea
H.J. Kim: College of Veterinary Medicine and Veterinary Science Research Institute, Konkuk University, Seoul, Republic of Korea
H.R. Lee: College of Veterinary Medicine and Veterinary Science Research Institute, Konkuk University, Seoul, Republic of Korea
S. Han: Hansu Animal Clinic, Seoul, Republic of Korea
S.H. Do: College of Veterinary Medicine and Veterinary Science Research Institute, Konkuk University, Seoul, Republic of Korea

Veterinární medicína, 2014, vol. 59, issue 9, 453-456

Abstract: Herein, we report the histopathology of angiokeratoma characterised by non-invasive, proliferative, ectatic vascular malformations accompanying lysosomal dilation in the canine skin. Two cutaneous angiokeratomas were diagnosed in a six-year-old spayed female Pekinese dog. Physical examination of the skin revealed two small erythematous papules on the axillary and abdominal regions. The masses were approximately 2-3 mm in diameter, well-circumscribed, purple to red in colour, and slightly elevated above the skin surface. The two small masses had similar histopathological features, characterised by exophytic proliferation of a mixture of multiple vascular channels resembling a cavernous haemangioma on the superficial dermis. The entire lesion was well circumscribed and the overlying epidermal hyperplasia formed a collarette. Ultrastructural analysis with transmission electron microscopy revealed electron-lucent lysosomal dilatation in the keratinocytes of the irregular hyperplastic epithelial trabeculae like rete pegs.

Keywords: angiokeratoma; haemangioma; lysosomal storage disease; transmission electron microscopy (search for similar items in EconPapers)
Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:59:y:2014:i:9:id:7686-vetmed

DOI: 10.17221/7686-VETMED

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