Biochemical, haematological and oxidative stress responses of common carp (Cyprinus carpio L.) after sub-chronic exposure to copper

M. Sevcikova, H. Modra, J. Blahova, R. Dobsikova, L. Plhalova, O. Zitka, D. Hynek, R. Kizek, M. Skoric and Z. Svobodova
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M. Sevcikova: University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
H. Modra: University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
J. Blahova: University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
R. Dobsikova: University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
L. Plhalova: University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
O. Zitka: Mendel University, Brno, Czech Republic
D. Hynek: Mendel University, Brno, Czech Republic
R. Kizek: Mendel University, Brno, Czech Republic
M. Skoric: University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
Z. Svobodova: University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

Veterinární medicína, 2016, vol. 61, issue 1, 35-50

Abstract: The aim of the present study was to investigate the impact of copper-based pesticides (at concentrations of copper of 20, 30, 40 and 70 µg/l) on one-year-old common carp (Cyprinus carpio L.) during 28 days of exposure. Abnormal behaviour was observed in fish exposed to 70 µg/lfrom Day14. Histological alterations were noticed only in liver in the groups exposed to 40 and 70 µg/l.Significant changes (P ˂ 0.05) in almost all haematological indices were found, especially in the group exposed to the highest concentration of copper (70 µg/l). Biochemical analysis revealed various significant (P ˂ 0.05) differences among the tested groups. Significant differences in copper tissue concentration (P ˂ 0.05) among groups were found in liver, gills and kidney. Among antioxidative enzymes, significant changes were revealed mainly in catalase and glutathione-S-transferase activity (P ˂ 0.05). In gills, metallothionein content increased significantly (P ˂ 0.05) in the group exposed to the highest copper concentration (70 µg/l) compared with the other tested groups, including the control. A significant (P ˂ 0.05) change in total glutathione content was recorded in liver and gills, although the reduced/oxidised ratio was not affected. Oxidative damage to lipids increased significantly (P ˂ 0.05) with increasing copper concentration in liver and kidney. The results demonstrate the deleterious influence of copper on common carp even at low, environmentally relevant concentrations.

Keywords: metals; fish; antioxidant defence; pesticides (search for similar items in EconPapers)
Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:61:y:2016:i:1:id:8681-vetmed

DOI: 10.17221/8681-VETMED

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