Successful response to imatinib in two dogs with inoperable grade III infiltrating mast cell tumours: a case report

J.H. Kim, H.J. Kim, D.H. Kim, J.H. Yim, S.J. Lee, K.H. Park and H.Y. Yoon
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J.H. Kim: Konkuk University Veterinary Medical Teaching Hospital, Seoul, Republic of Korea
H.J. Kim: Konkuk University Veterinary Medical Teaching Hospital, Seoul, Republic of Korea
D.H. Kim: College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea
J.H. Yim: College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea
S.J. Lee: College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea
K.H. Park: College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea
H.Y. Yoon: College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea

Veterinární medicína, 2016, vol. 61, issue 8, 467-473

Abstract: Two dogs were presented owing to sudden rapid growth of cutaneous masses greater than 10 cm on the neck and axillary region, respectively. Based on history and results of physical examinations, blood work, fine needle aspiration, histopathological examination, and computed tomography, inoperable grade III infiltrating mast cell tumours were diagnosed. After the initiation of imatinib treatment, the masses markedly shrank and became undetectable within 10 days in both dogs, although none of the tumour specimens showed evidence of mutations in sequencing of c-kit exons 8 and 11. These results suggest that imatinib could be a therapeutic option in patients with surgically inoperable canine mast cell tumours, even those that are histopathologically high grade without c-kit exon 8 or 11 mutations.

Keywords: canine; KIT; oncogene; target therapy; tyrosine kinase inhibitor (search for similar items in EconPapers)
Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:61:y:2016:i:8:id:87-2016-vetmed

DOI: 10.17221/87/2016-VETMED

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