Improvement of systemic lupus erythematosus in dogs with canine adipose-derived stem cells

Minho Ko, Tae Hyeong Kim, Yoonhwan Kim, Doo Kim, Jin-Ok Ahn, Byung-Jae Kang, Sooyoung Choi, Inchul Park, Jung Hoon Choi and Jin Young Chung
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Minho Ko: Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea
Tae Hyeong Kim: Department of Veterinary Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea
Yoonhwan Kim: Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea
Doo Kim: Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea
Jin-Ok Ahn: Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea
Byung-Jae Kang: Department of Veterinary Surgery, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea
Sooyoung Choi: Department of Veterinary Diagnostic Imaging, College of Veterinary Medicine, Kangwon National University, Gangwondo, Republic of Korea
Inchul Park: Department of Veterinary Diagnostic Imaging, College of Veterinary Medicine, Kangwon National University, Gangwondo, Republic of Korea
Jung Hoon Choi: Department of Veterinary Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea
Jin Young Chung: Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Republic of Korea

Veterinární medicína, 2019, vol. 64, issue 10, 462-466

Abstract: A 6-year-old, intact female, Maltese presented with limited movement of the hind limbs and intermittent pruritus for three months. The patient was diagnosed with systemic lupus erythematosus. Conventional immunosuppressive therapy was attempted for 70 days; however, the patient still suffered from life-threatening pancreatitis and hepatopathy. Therefore, we tried canine adipose-derived mesenchymal stem cells for immunomodulation and liver protection. After 6-months of the stem cell therapy, the patient's walking and hepatopathy improved. These findings indicate that stem cell therapy may be another option for systemic lupus erythematosus in dogs.

Keywords: dog; SLE; stem cell therapy (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:64:y:2019:i:10:id:46-2019-vetmed

DOI: 10.17221/46/2019-VETMED

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