Long-term management of canine disseminated granulomatous meningoencephalitis with imatinib mesylate: a case report

Joong Hyun Song, Tae Sung Hwang, Hee Chun Lee, Do Hyeon Yu, Byung Joon Seung, Jung Hyang Sur and Dong In Jung
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Joong Hyun Song: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
Tae Sung Hwang: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
Hee Chun Lee: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
Do Hyeon Yu: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
Byung Joon Seung: College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea
Jung Hyang Sur: College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea
Dong In Jung: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea

Veterinární medicína, 2019, vol. 64, issue 2, 92-99

Abstract: A seven-year-old Toy Poodle was presented for progressive ataxia and seizure episodes. Magnetic resonance imaging revealed inflammatory lesions in the cerebrum and brainstem. Management with imatinib mesylate, prednisolone and hydroxyurea were initiated and resulted in complete resolution of the clinical signs. In regular magnetic resonance imaging scans, the overall appearance of the lesions deteriorated but improved again after an increase in the imatinib mesylate dose. The patient had not shown any neurological signs until death and survived for 1052 days after initial presentation. On histopathological examination, the patient was diagnosed with disseminated granulomatous meningoencephalitis involving the cerebrum and brainstem. Immunohistochemical staining was performed on the five types of tyrosine kinase (PDGFR-α, PDGFR-ß, VEGFR-2, c-Kit and c-Abl proteins), which constitute therapeutic targets for conventional multitargeted tyrosine kinase inhibitors. The immunohistochemical analysis revealed that all these tyrosine kinases were expressed in the brain samples. The present report describes the first case of the use of imatinib mesylate therapy for granulomatous meningoencephalitis in the dog. Therapy with imatinib mesylate plus glucocorticoids appears promising as a new therapeutic intervention in meningoencephalitis of unknown aetiology.

Keywords: dog; immunohistochemical staining; magnetic resonance imaging; unknown aetiology; tyrosine kinase; tyrosine kinase inhibitor (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:64:y:2019:i:2:id:70-2018-vetmed

DOI: 10.17221/70/2018-VETMED

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