Mycophenolate mofetil plus prednisolone combination therapy for necrotising leukoencephalitis in a dog: long-term clinical observation, serial imaging analysis and histopathological findings

Su Jin An, Joon Hyeok Jeon, Do Hyeon Yu, Joong Hyun Song, Hee Chun Lee, Ki Chang Lee, Jung Hyang Sur and Dong In Jung
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Su Jin An: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
Joon Hyeok Jeon: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
Do Hyeon Yu: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
Joong Hyun Song: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
Hee Chun Lee: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea
Ki Chang Lee: College of Veterinary Medicine, Chonbuk National University, Jeonju, Republic of Korea
Jung Hyang Sur: Department of Pathobiology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea
Dong In Jung: Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea

Veterinární medicína, 2019, vol. 64, issue 8, 373-378

Abstract: An 8-year-old intact male mixed-breed dog presented with tetraparesis, right side head tilt, and cluster seizure-like episodes. Based on the magnetic resonance imaging and cerebrospinal fluid analysis results, meningoencephalitis of an unknown aetiology was strongly suspected. The patient survived for 963 days under mycophenolate mofetil plus prednisolone therapy and was ultimately diagnosed with necrotising leukoencephalitis. This report describes the clinical findings, the serial magnetic resonance imaging characteristics, and the histopathologic features of a case of necrotising leukoencephalitis and the long-term survival after mycophenolate mofetil plus prednisolone therapy.

Keywords: autoimmune encephalitis; magnetic resonance imaging (MRI); meningoencephalitis of an unknown aetiology (MUE); necrotising meningoencephalitis (NME) (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:64:y:2019:i:8:id:116-2018-vetmed

DOI: 10.17221/116/2018-VETMED

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