Comparative effectiveness of interventions for treating interdigital necrobacillosis in cattle: A network meta-analysis

Torehanov Ma, Tulemissova Zk, Ibazhanova As, Rafikova Er, B Muzapbarov, Korabaev Em and Siyabekov St
Additional contact information
Torehanov Ma: Department of Biological Safety, Kazakh National Agrarian University, Almaty, Kazakhstan
Tulemissova Zk: Department of Biological Safety, Kazakh National Agrarian University, Almaty, Kazakhstan
Ibazhanova As: Department of Biological Safety, Kazakh National Agrarian University, Almaty, Kazakhstan
Rafikova Er: Department of Pharmacology and General Pathology, Faculty of Veterinary Medicine, Novosibirsk State Agrarian University, Novosibirsk, Russian Federation
B Muzapbarov: Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Korabaev Em: Department of Biological Safety, Kazakh National Agrarian University, Almaty, Kazakhstan
Siyabekov St: Department of Biological Safety, Kazakh National Agrarian University, Almaty, Kazakhstan

Veterinární medicína, 2021, vol. 66, issue 11, 461-469

Abstract: The aim of this study was to comparatively evaluate the efficacy of different antimicrobial agents against interdigital necrobacillosis (IN) in cattle to identify the treatment with the greatest benefit. A network meta-analysis was used to synthesise empirical results from randomised controlled trials. Four studies with five interventions for 565 animals were included. The meta-analysis found no significant differences between the risk ratios for the antimicrobials versus placebo. However, ceftiofur sodium administered intramuscularly at a dose of 1.0 µg/kg body weight every 24 h for 3 days showed a better clinical response than 6.6 µg of oxytetracycline, 2.5 µg of tulathromycin, the placebo and 0.1 µg of ceftiofur sodium. The results show the best efficacy for 6.6 µg of oxytetracycline and 1.0 µg of ceftiofur sodium. Nevertheless, the latter is likely to be superior to oxytetracycline in terms of its pharmacodynamic and pharmacokinetic properties. Thus, 1.0 µg of ceftiofur sodium appears to provide the best therapeutic activity against IN in cattle. Further well-designed studies are required.

Keywords: antibiotic; ceftiofur sodium; foot rot; oxytetracycline; tulathromycin (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
http://vetmed.agriculturejournals.cz/doi/10.17221/232/2020-VETMED.html (text/html)
http://vetmed.agriculturejournals.cz/doi/10.17221/232/2020-VETMED.pdf (application/pdf)
free of charge

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:66:y:2021:i:11:id:232-2020-vetmed

DOI: 10.17221/232/2020-VETMED

Access Statistics for this article

Veterinární medicína is currently edited by Ing. Helena Smolová Ph.D.

More articles in Veterinární medicína from Czech Academy of Agricultural Sciences
Bibliographic data for series maintained by Ivo Andrle ().