Effect of Bacillus subtilis on the microarchitectural development of the immune system in Salmonella-challenged broiler chickens

A Sikandar, H Zaneb, A Nasir, A Rehman, M Kashif, M Shah, Z Luqman, S Din, Iqbal Mf, I Khan and I Irshad
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A Sikandar: Sub-campus, Jhang, University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan
H Zaneb: Department of Anatomy and Histology, University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan
A Nasir: Sub-campus, Jhang, University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan
A Rehman: Sub-campus, Jhang, University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan
M Kashif: Sub-campus, Jhang, University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan
M Shah: Department of Animal Health, The University of Agriculture, Peshawar, Pakistan
Z Luqman: Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
S Din: Department of Anatomy and Histology, University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan
Iqbal Mf: Pir Mehr Ali Shah - Arid Agriculture University (PMAS AAUR), Rawalpindi, Pakistan
I Khan: College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University, Mardan, Pakistan
I Irshad: Department of Pathology, University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan

Veterinární medicína, 2022, vol. 67, issue 1, 28-37

Abstract: The effect of Bacillus subtilis on the immune responses and morphometry of the immune organs was evaluated in broilers challenged with S. gallinarum. For this purpose, Salmonella-free birds (n = 240) were split into four groups with six replicates of ten birds each. Groups included an NC (negative control, non-infected + non-medicated), a PC-S (positive control, Salmonella-infected + non-medicated), an AT-S (Salmonella-infected + medicated with enrofloxacin), and a BS-S (Salmonella-infected + B. subtilis (2.0 × 1010 cfu/g; 0.1 g/kg) group. On day 21, the thickness of the thymus cortex and medulla, germinal centre area of the spleen, bursal follicular length and bursal follicular area increased (P < 0.05) in the BS-S when compared to the NC and PC-S groups. On day 35, the BS-S group exhibited a higher (P < 0.05) antibody titre against the Newcastle disease virus (NDV), and cortex of the thymus was thicker (P < 0.05) compared to the other groups. A decrease in the thymus medulla thickness, germinal area of the spleen and bursal follicular number were noted in the PC-S group when compared to the other treatment groups. In conclusion, the prophylactic use of B. subtilis type probiotics alleviated the stress resulting from a Salmonella gallinarum infection and improved the immune organs development and function in infected broilers.

Keywords: histopathology; immunity; organs; poultry; probiotic; salmonellosis (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:67:y:2022:i:1:id:231-2020-vetmed

DOI: 10.17221/231/2020-VETMED

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