Riboflavin/UV-A corneal phototherapy as stand-alone management of ulcerative keratitis in dogs

A Marchegiani, R Gialletti, Cassarani Mp, M Cerquetella, Attili Ar, G Lombardo, M Lombardo, A Spaterna and R Arcelli
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A Marchegiani: School of Biosciences and Veterinary Medicine, University of Camerino, Matelica (Macerata), Italy
R Gialletti: Department of Veterinary Medicine, University of Perugia, Perugia, Italy
Cassarani Mp: School of Biosciences and Veterinary Medicine, University of Camerino, Matelica (Macerata), Italy
M Cerquetella: School of Biosciences and Veterinary Medicine, University of Camerino, Matelica (Macerata), Italy
Attili Ar: School of Biosciences and Veterinary Medicine, University of Camerino, Matelica (Macerata), Italy
G Lombardo: CNR-IPCF, Istituto per i Processi Chimico-Fisici, Messina, Italy
M Lombardo: Vision Engineering Italy srl, Rome, Italy
A Spaterna: School of Biosciences and Veterinary Medicine, University of Camerino, Matelica (Macerata), Italy
R Arcelli: Department of Veterinary Medicine, University of Perugia, Perugia, Italy

Veterinární medicína, 2022, vol. 67, issue 4, 190-198

Abstract: Corneal ulcers are one of the most common ocular disorders in veterinary ophthalmology and several factors can negatively influence the efficacy of the currently available therapeutic options, leading to a loss of corneal transparency and, thus, vision. Twenty-five dogs with clinical signs of corneal ulcers were randomised to receive either corneal phototherapy (16 dogs; study group) or topical standard medical therapy (9 dogs; control group). The riboflavin/UV-A corneal phototherapy (PACK-CXL) consisted in the application of a riboflavin ophthalmic solution (Visioflavin®; Vision Engineering Italy srl, Rome, Italy) onto the cornea for 20 min followed by 30 mW/cm2 UV-A irradiance for 3 min using a point-of-care UV-A device (Vetuvir®; Vision Engineering Italy srl, Rome, Italy). The complete healing of the ulcerative lesion was defined as the complete restoration of the corneal epithelial integrity with negative fluorescein staining. The corneal phototherapy achieved complete corneal healing in all the dogs by 20.5 ± 7.8 days. In the control group, only two dogs achieved complete healing by 21.5 ± 15.6 days. This intervention may represent a valid option to hasten corneal wound healing and a clinical resolution of ulcerative keratitis in dogs.

Keywords: corneal melting; corneal ulcer; cross-linking; keratitis; riboflavin; UV-A (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:67:y:2022:i:4:id:46-2021-vetmed

DOI: 10.17221/46/2021-VETMED

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