Treatments and therapeutic protocols for the recovery of an asphyxiated new-born: A review of pre-clinical and clinical studies in human neonates and in different animal models

P Islas-Fabila, H Orozco-Gregorio, P Roldan-Santiago, M Waytula, M Gonzalez-Hernandez, X Vega- Manriquez, Jimenez-Collado Ca and H Bonilla-Jaime
Additional contact information
P Islas-Fabila: Doctoral Program in Biological Sciences and Health, Universidad Autónoma Metropolitana, México City, México
H Orozco-Gregorio: Private Professional Practice, México City, México
P Roldan-Santiago: Reproduction Department, Faculty of Veterinary Medicine and Zootechnics, Universidad Nacional Autónoma de México, México City, México
M Waytula: School of Veterinary Medicine and Zootechnics, Universidad del Valle de México, Coyoacán, Ciudad de México, México
M Gonzalez-Hernandez: Faculty of Agronomy and Veterinary, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México
X Vega- Manriquez: Faculty of Agronomy and Veterinary, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México
Jimenez-Collado Ca: General Director of Laboratorios Manuell S.A., Morelos, México City, México
H Bonilla-Jaime: Department of Reproductive Biology, Universidad Autónoma Metropolitana, México City, México

Veterinární medicína, 2022, vol. 67, issue 6, 271-297

Abstract: The objective of this review is to ascertain the advantages and disadvantages of several treatments and therapeutic protocols that have been used for the prevention and treatment of perinatal asphyxia in human neonates and in different animal models. Perinatal asphyxia is one of the main causes of mortality worldwide and is an important factor in triggering physio-metabolic disorders that result in serious neurological consequences and learning disorders not only in human foetuses and neonates, but also in animals. In recent years, the search for new pharmacological protocols to prevent and reverse physio-metabolic disorders and brain damage derived from perinatal asphyxia has been and continues to be the subject of intense research. Currently, within these pharmacological protocols, therapeutic strategies have been evaluated that use respiratory and hormonal stimulants, as well as hypothermic therapies in combination with other putative neuroprotective agents. Similarly, energy supplements have been evaluated with the objective of preventing perinatal asphyxia and treating new-borns with this condition, and to decrease the incidence of neonatal and foetal deaths associated with it. However, despite these promising advances, this pathology has persisted, since the administration of these therapies in low doses may not exert a neuroprotective effect or, in high doses, can trigger adverse effects (such as reduced cardiac contractility, reduced cerebral blood flow, poor perfusion, sympathetic and neuroendocrine stimulation, and increased blood viscosity) in human foetuses and neonates as well as in different animal models (rats, piglets, sheep and rabbits). Therefore, it is important to determine the minimum effective dose with which these therapies exert a neuroprotective effect, as well as the mode of administration, the duration of therapy, etc. Therefore, until a powerful strategy is found to improve the consequences of suffocation, this topic will continue to be the subject of intensive research in the future.

Keywords: hypoxic-ischemic encephalopathy; neonatal mortality; perinatal asphyxia (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:67:y:2022:i:6:id:43-2021-vetmed

DOI: 10.17221/43/2021-VETMED

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