NEW INSIGHTS IN THE DESIGN OF NANOPARTICLES ENTRAPPING DICLOFENAC

Ana-Maria Păuna, Gratiela Eliza Popa and Liliana Mititelu-TARȚĂU
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Ana-Maria Păuna: Doctoral School University of Medicine and Pharmacy "Grigore T. Popa"; Faculty of Medicine, Department of Pharmacology, Clinical Pharmacology and Algesiology
Gratiela Eliza Popa: University of Medicine and Pharmacy "Grigore T. Popa"; Faculty of Pharmacy, Department of Pharmaceutical Technology
Liliana Mititelu-TARȚĂU: University of Medicine and Pharmacy "Grigore T. Popa"; Faculty of Medicine, Department of Pharmacology, Clinical Pharmacology and Algesiology

SEA - Practical Application of Science, 2019, issue 21, 243-248

Abstract: Nanoparticles have a special place in nanoscience and nanotechnology, not only because of their particular properties resulting from their reduced dimensions, but also because they are promising building blocks for more complex nanostructures. Diclofenac is an anti-inflammatory drug that inhibits cyclooxygenase (COX)-2 enzyme with greater potency than COX-1 does. The adverse effects can occur when NSAIDs are used for a long time, leading to gastrointestinal and renal dysfunctions. Nanoparticles of diclofenac are nanotransporters that facilitate the intracellular penetration and can reduce the side-effects of uncorporated diclofenac. Nanoparticles incorporating diclofenac have been made using various polymers and different stabilizers. The most important parameters in the characterization of nano-systems are the particle size and their size distribution in the colloidal solution, the Zeta potential, the polymorphism, the crystallization level, the degree of drug loading and its release profile.

Keywords: Nanoparticles; Diclofenac; NSAIDs (search for similar items in EconPapers)
Date: 2019
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