Eco-friendly Synthesis, Characterization and Antimicrobial Activity of Transition Metal Complexes of Schiff Base Ligand Derived from 1H-indole-3-carbaldehyde with 3-methylpyridine-4-carbohydrazide

Sadashiv N. Sinkar

International Journal of Scientific Research in Chemistry, 2026, vol. 11, issue 3, 15-23

Abstract: A Novel Schiff base ligand derived from (E)-N'-((1H-indol-3-yl) methylene)-3-methylpyridine-4-carbohydrazide was synthesized, along with its transition metal complexes of Mn (II), Co (II), Ni (II), Cu (II), and Zn (II), using microwave irradiation as a green approach, contrasting with conventional methods. The structure of these compounds was thoroughly characterized through elemental and spectroscopic analyses, including IR, 1H-NMR, and electronic spectra, elucidating their geometrical arrangements. Furthermore, the thermal stability of the Mn (II) and Co (II) complexes was investigated via thermo-gravimetric analyses (TGA). Elemental analysis confirmed a metal-to-ligand stoichiometry of 1:2 molar ratio. Additionally, the complexes were screened for their potential biological activities, particularly antimicrobial properties.

Keywords: Microwave synthesis; Novel ligand; TGA; biological activity (search for similar items in EconPapers)
Date: 2026
Note: Article URL: https://ijsrch.com/home/article/view/IJSRCH261132
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