Binary Complex Formation of Transition Metal Ions with Amoxicillin Trihydrate: Potentiometric Studies

Abhijit V. Bachute and Bhagwansing S. Dobhal

International Journal of Scientific Research in Chemistry, 2024, vol. 9, issue 5, 47-55

Abstract: The present work deals with the potentiometric determination of stability constants of binary complexes of transition metal ions with amoxicillin trihydrate in aqueous medium. The complexation behaviour of biologically important transition metal ions such as Cu(II), Ni(II), Co(II), Zn(II), Cd(II) and Fe(II) with amoxicillin trihydrate has been studied by the potentiometric titration technique at constant ionic strength and temperature using an ELICO Model L-120 pH Meter. The proton-ligand and metal-ligand stability constants were obtained from the potentiometric titration data in order to have a better insight into the coordination tendencies of the ligand towards different metal ions. The complexation of Cd(II) with amoxicillin trihydrate was stable but the complexation process seemed to be a little slow as compared, which was reflected by the longer buffering region in the titration curve. The relative stability of the metal–amoxicillin complexes may be approximately represented in the order: Fe(II) ≈ Ni(II) > Cu(II) > Co(II) ≈ Zn(II) > Cd(II), as reveals from the potentiometric behavior and the extent of curve deviation. The order of stability observed has been interpreted in terms of ionic radius, electronic configuration and ligand field stabilization effects. The study provides valuable insight into the coordination chemistry, metal binding behavior and solution equilibria of the transition metal complexes with amoxicillin trihydrate.

Keywords: Amoxicillin trihydrate; Potentiometric titration; Transition metal complexes; Stability constants; Binary complexes (search for similar items in EconPapers)
Date: 2024
Note: Article URL: https://ijsrch.com/home/article/view/IJSRCH2495351
References: Add references at CitEc
Citations:

Downloads: (external link)
https://ijsrch.com/home/article/view/IJSRCH2495351 Article URL (text/html)
https://ijsrch.com/home/article/download/IJSRCH2495351/IJSRCH2495351 Full text (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:cuo:ijsrch:v9:y2024:i5:id:86

DOI: 10.32628/IJSRCH2495351

Access Statistics for this article

More articles in International Journal of Scientific Research in Chemistry from International Journal of Scientific Research in Chemistry
Bibliographic data for series maintained by Pankaj Sharma ().