Differential Expression Analysis of RNA-Binding Proteins in Chronic Myeloid Leukemia Progression

Mengzhan Liu
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Mengzhan Liu: Amador Valley High School, Pleasanton, 94566, US

Current Research in Medical Sciences, 2025, vol. 4, issue 4, 49-56

Abstract: Background: Chronic myeloid leukemia (CML) progresses from chronic phase (CP) to blast phase (BP) through poorly understood molecular mechanisms. Previous transcriptomic studies identified widespread splicing alterations in CML, yet systematic analysis of RNA-binding protein (RBP) expression patterns across disease stages remains limited. Methods: We performed computational analysis of RNA-seq data from peripheral blood mononuclear cells of 5 CP patients, 5 BP patients, and 5 healthy controls. Expression data for 540 RBPs were extracted and compared between groups using a significance threshold of p

Keywords: chronic myeloid leukemia; RNA-binding proteins; differential expression; chronic phase; blast phase; post-transcriptional regulation (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:cvg:curmsc:v:4:y:2025:i:4:p:49-56

DOI: 10.56397/CRMS.2025.09.06

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